Publication bias is “the tendency for researchers, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study's findings” (Dickersin, 1990) . It is also called the “file-drawer effect” because it is taught that unpublished results hidden in filing cabinets by researchers could cause invalid meta-analyses of that research (Scargle, 1999). Many studies confirm that publication bias is a serious problem, such as the study conducted by researchers at the University of Oregon Health and Science that examined the trial approval process for 12 separate antidepressants submitted to the FDA (Turner, 2008). They found that only 3/36 tracks with negative results were released compared to 37/38 positive tracks. Publishing negative results is essential to interpreting the overall meaning of the research field and this problem needs to be resolved. There are numerous concerns related to publication bias. Research is becoming less innovative and its neutrality is decreasing. Well-conducted studies may be repeated unnecessarily due to increased underreporting of negative studies. Reviews of published data have become increasingly distorted by this reporting imbalance. Valuable time, resources and funding are wasted that could be used for other useful research. Another concern is that doctors may make costly health decisions by overestimating the benefits and underestimating the harms caused by not publishing negative results. The famous cover-up of the negative effects of the anti-inflammatory drug Rofecoxib (Vioxx) is an example of how hiding negative results can harm patients (Curfman, 2005). Rofecoxib has been prescribed to 80 million people. After 5 years, it was revealed that the founding company, Merck,...... halfway through the document...... training." Food and Drug Administration Amendments Act (FDAAA) of 2007. FDA, December 2, 2011 . Web. November 23, 2013.Scargle, Jeffrey D. “Publication Bias (the “File Drawer Problem”) in Scientific Inference.” How do we measure it? How do we avoid it?" Dovepress Journal, July 2013. Web. November 23, 2013. Turner, Erick H., et al. "Selective publication of antidepressant studies and its influence on apparent efficacy." New England Journal of Medicine 358.3 ( 2008): 252-260. Watkins, Tom. “Documents Indicate Company Knew of Possible Suicide Risk with Prozac.” CNN Cable News Network, January 3, 2005. Web, November 23, 2013. Wood, Susan F. and Kristen L. Perosino. “Increasing Transparency at the FDA: The Impact of FDA Amendments Act Public Health Reporting".123.4 (2008): 527.