Background Nutrition plays a significant role in the human life cycle because it provides energy, prevents disease, and promotes growth. Scientists have identified the role of dietary involvement in the aging process. The role of low-calorie diets arouses interest among scientists in the field of gerontology and results in numerous research studies. Calorie restriction (CR) refers to a 10-40% reduction in intake of a healthy, nutritious diet. Scientists identify it as the primary non-genetic mechanism that prolongs longevity (Mattison, et al., 2012). A study by McCay et al. in 1930 (Heilbronn & Ravussin, 2005) provided evidence that CR slows aging and extends human lifespan. Calorie restriction is applicable at any stage of the life cycle, but the goal should be to ensure consumption of a healthy diet. Physiological changes related to aging include cell damage and the appearance of cancerous cells. Low-calorie diets in old age help eliminate these cells (Spingler & Dhahbi, 2007). As a result, studies on the impact of CR in rodents and primates show that it improves lifespan by up to 40% with a nutritious diet (Fight Aging, n.d.). Research studies also show that longevity increases with increased calorie restriction (refer to Figure 1). Furthermore, research studies have attempted to establish the mechanism by which CR increases human lifespan. Calorie restriction improves lifespan by delaying and preventing chronic disease and through independent mechanisms. Researchers propose mechanisms such as reduced metabolic rates and slow sexual maturation. However, recent studies suggest that the primary mechanism is the preservation of the stress response in most animals (Heilbronn & Ravussin, 2005). Another research study proposes that CR slows the aging process by preventing the inactivation of peroxiredoxin (Molin, et al., 2011). For CR to work