BackgroundMany parents express concern and concern about their children developing a fever after receiving vaccines. For this reason, parents often choose to treat their children with antipyretics to prevent this unpleasant side effect. According to Pedulla (2012), it was previously common practice by pediatric health services to recommend the use of an antipyretic before the administration of vaccinations in order to reduce fever and discomfort experienced by the patient until a study conducted by Prymula and colleagues in 2009 showed evidence that these types of drugs caused a decline in the primary antibody response. Current practice in most pediatric clinics is not standardized regarding the administration of antipyretics and vaccinations. There are health care providers who will order a dose of acetaminophen to be given to a child before administering vaccinations, some providers send patients home with a prescription for acetaminophen or ibuprofen to be administered once the child returns home, still others tell the parents to avoid the vaccine. use of paracetamol or ibuprofen until the child actually has a fever. So which practice is correct? Does the prophylactic use of antipyretics before the administration of vaccinations decrease the effectiveness of the vaccine? What education should be given to parents regarding the use of paracetamol and ibuprofen before vaccinations? These are the questions underlying the proposal to research the results of the administration of antipyretics, such as paracetamol and ibuprofen, before immunization and its effect on the effectiveness of the vaccine. Significance Statement When it comes to immunizations, nurses are on the front lines. Most childhood vaccinations are administered by nurses in various... half of paper ......rics, 13(1), 98.Simmons, S. (1990). The health-promoting self-care system model: directions for nursing research and practice. Journal of Advanced Nursing, 15(10), 1162-1166. doi:10.1111/j.1365-2648.1990.tb01708.xSorensen, R., Paris, K. (2012). Evaluation of the immunological response to vaccination. In R. Stiehm (ed.), UpToDate. Retrieved from http://www.uptodateonline.com.Sullivan, J. E., & Farrar, F. C. (2011). Fever and antipyretic use in children. Pediatrics, 127(3), 580-587. US Department of Health and Human Services. (2009). Code of Federal Regulations: Protection of Human Subjects. Retrieved from http://www.hhs.gov/ohrp/humansubjects/commonrule/Wallenstein, M.B., Schroeder, A.R., Hole, M.K., Ryan, C., Fijalkowski, N., Alvarez, E., & Carmichael, S.L. ( 2012). Fever literacy and fever phobia. Clinical Pediatrics, 52(3), 254-259. doi:10.1177/0009922812472252