1. IntroductionBotulism or sausage poisoning, name "botulism" similar to "botulus" in the Latin word meaning sausage, was first recognized in the late 1700s after the disease occurred in southern Germany. Around 1820, German neurologist Justinus Kerner studied and explained that the disease was related to the ingestion of spoiled sausages. Kerner isolated the substance from the sausage and described that the sausage contained a poisonous substance that had been diagnosed with clinical signs related to botulism, but the deadly poison was still unknown. In 1895, the offending etiological agent in the vitiation was discovered to be a bacterium which is Clostridium botulinum (C. botulinum) by Emile Van Ermengem and published in 1897 (Julie and Dorothy, 2007). The bacterium Clostridium botulinum is a Gram-positive anaerobic bacillus and is caused by the action of botulinum neurotoxin (BoNT). Common property of spore production by C. botulinumn which has high resistance to physical and chemical agents. Resistant spores can spread worldwide in the biosphere and spread in soil, dust, water, vapors, both fresh and salty mud, as well as sewage and finally can contaminate various foods. Under optimal nutritional and physical conditions for C. botulinumn (anaerobiosis, low acid level with pH above 4.5, low salt and sugar concentration, sufficient amount of nutrients) a vegetative cell is formed which eventually becomes BoNT from spores. At a temperature of 100°C, these organisms are able to survive for up to 2 hours. C. botulinumn has a very efficient neurotoxin, a mouse is killed by just 10 picograms of neurotoxin and 1 nanogram per kilogram of body mass is a toxic dose for humans. At temperatures of 85°C, these neurotoxins are heat-labile and rapidly inactive...... middle of paper... imens. One of the treatments is botulism antitoxin whose effects are specific to the early stage of the disease, if it is detected in the advanced stage, this antitoxin does not have good effects on the disease. The use of nutritional support and rehabilitation to improve neurocognitive function is also used to alleviate. In some cases, part of the motor paralysis may use guanidine hydrochloride (50 mg/kg) to reverse the paralysis (Teguh et al., 2007).6. Personal Perspective and CommentsTubulism is an important disease because it causes an environment involving water, soil, air, and animal debris contaminated with C. botulinum. This bacterium can generate BoNT to inhibit the release of acetylcholine and cause flaccid paralysis. The best and simplest way to protect your body is to eat cooked food, drink hot water to kill bacteria before consumption, and wear a mask against bacteria when working in potentially contaminated environments..